Modeling structurally variable regions in homologous proteins with rosetta.

@article{Rohl2004ModelingSV,
  title={Modeling structurally variable regions in homologous proteins with rosetta.},
  author={Carol A. Rohl and Charlie E. M. Strauss and Dylan Chivian and David Baker},
  journal={Proteins},
  year={2004},
  volume={55 3},
  pages={656-77}
}
A major limitation of current comparative modeling methods is the accuracy with which regions that are structurally divergent from homologues of known structure can be modeled. Because structural differences between homologous proteins are responsible for variations in protein function and specificity, the ability to model these differences has important… CONTINUE READING