Modeling steady state SO2-dependent changes in capillary ATP concentration using novel O2 micro-delivery methods

@inproceedings{Ghonaim2013ModelingSS,
  title={Modeling steady state SO2-dependent changes in capillary ATP concentration using novel O2 micro-delivery methods},
  author={Nour W. Ghonaim and Graham M Fraser and Christopher Gerald Ellis and Jun Yang and Daniel Goldman},
  booktitle={Front. Physiol.},
  year={2013}
}
Adenosine triphosphate (ATP) is known to be released from the erythrocyte in an oxygen (O2) dependent manner. Since ATP is a potent vasodilator, it is proposed to be a key regulator in the pathway that mediates micro-vascular response to varying tissue O2 demand. We propose that ATP signaling mainly originates in the capillaries due to the relatively long erythrocyte transit times in the capillary and the short ATP diffusion distance to the electrically coupled endothelium. We have developed a… CONTINUE READING

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SO2 and corresponding [ ATP ] changes were also modeled in a terminal arteriole ( 9 μm in diameter ) that replaces 4 surface capillaries in the idealized network geometry .
SO2 and corresponding [ ATP ] changes were also modeled in a terminal arteriole ( 9 μm in diameter ) that replaces 4 surface capillaries in the idealized network geometry .
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