Modeling small-molecule release from PLG microspheres: effects of polymer degradation and nonuniform drug distribution.

Abstract

Modeling release of small molecules from degradable microspheres is important to the design of controlled-release drug delivery systems. Release of small molecules from poly(d,l-lactide-co-glycolide) (PLG) particles is often controlled by diffusion of the drug through the polymer and by polymer degradation. In this study, a model is developed to… (More)

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