Modeling proximal tubule cell homeostasis: tracking changes in luminal flow.

@article{Weinstein2009ModelingPT,
  title={Modeling proximal tubule cell homeostasis: tracking changes in luminal flow.},
  author={Alan M. Weinstein and Eduardo D. Sontag},
  journal={Bulletin of mathematical biology},
  year={2009},
  volume={71 6},
  pages={1285-322}
}
During normal kidney function, there are routinely wide swings in proximal tubule fluid flow and proportional changes in Na(+) reabsorption across tubule epithelial cells. This "glomerulotubular balance" occurs in the absence of any substantial change in cell volume, and is thus a challenge to coordinate luminal membrane solute entry with peritubular membrane solute exit. In this work, linear optimal control theory is applied to generate a configuration of regulated transporters that could… CONTINUE READING