Modeling protein conformational transitions by a combination of coarse-grained normal mode analysis and robotics-inspired methods

@inproceedings{AlBluwi2013ModelingPC,
  title={Modeling protein conformational transitions by a combination of coarse-grained normal mode analysis and robotics-inspired methods},
  author={Ibrahim Al-Bluwi and Marc Vaisset and Thierry Sim{\'e}on and Juan Cort{\'e}s},
  booktitle={BMC Structural Biology},
  year={2013}
}
Obtaining atomic-scale information about large-amplitude conformational transitions in proteins is a challenging problem for both experimental and computational methods. Such information is, however, important for understanding the mechanisms of interaction of many proteins. This paper presents a computationally efficient approach, combining methods originating from robotics and computational biophysics, to model protein conformational transitions. The ability of normal mode analysis to predict… CONTINUE READING

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