Modeling plasma lipoprotein-bile lipid relationships: differential impact of psyllium and cholestyramine in hamsters fed a lithogenic diet.

@article{Trautwein1993ModelingPL,
  title={Modeling plasma lipoprotein-bile lipid relationships: differential impact of psyllium and cholestyramine in hamsters fed a lithogenic diet.},
  author={Eike A. Trautwein and Anis Siddiqui and Kenneth C. Hayes},
  journal={Metabolism: clinical and experimental},
  year={1993},
  volume={42 12},
  pages={
          1531-40
        }
}
Increased fecal bile acid excretion and changes in the circulating bile acid pool are involved in the hypocholesterolemic and gallstone-preventive actions of psyllium in hamsters.
TLDR
Increased fecal bile acid excretion and alterations of the circulating bileacid pool by removal of dihydroxy bile acids appear to be main modulators of the hypocholesterolemic action of PSY by leading to an up-regulation of hepatic bile Acid synthesis.
Cholesterol, bile acid, and lipoprotein metabolism in two strains of hamster, one resistant, the other sensitive (LPN) to sucrose-induced cholelithiasis.
TLDR
It is indicated that LPN hamsters have a genetic predisposition to sucrose-induced cholesterol gallstone formation related to differences in cholesterol and bile acid metabolism.
Effect of different varieties of pectin and guar gum on plasma, hepatic and biliary lipids and cholesterol gallstone formation in hamsters fed on high-cholesterol diets
TLDR
It is demonstrated that dietary pectins and guar gums had only minor effects on cholesterol metabolism and did not prevent cholesterol gallstone formation in this hamster model.
Dietary inulin lowers plasma cholesterol and triacylglycerol and alters biliary bile acid profile in hamsters.
TLDR
The data demonstrate that the lipid-lowering action of inulin is possibly due to several mechanisms, including altered hepatic triacylglycerol synthesis and VLDL secretion and impaired reabsorption of circulating bile acids.
Characterization of the bile acid profile in developing male and female hamsters in response to dietary cholesterol challenge.
Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine.
TLDR
Beta-cyclodextrin (BCD) prevented cholesterol gallstone formation by decreasing specifically the reabsorption of chenodeoxycholate, stimulating its biosynthesis and favoring its fecal elimination, and had a milder effect on lipid metabolism than cholestyramine.
Effects of dietary cholesterol and triglycerides on lipid concentrations in liver, plasma, and bile
TLDR
The results indicate that enhanced secretion of biliary CHL and, to a lesser extent, increased synthesis of hepatic CE, may be primary mechanisms for maintaining the hepatic FC pool.
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To evaluate the impact of key dietary factors on plasma lipoproteins and gallstone induction, male Syrian hamsters were fed either cholesterol and fat-supplemented purified diets containing glucose
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TLDR
The bile acid/cholesterol ratio was lower in animals on the cholesterol stone inducing diet and was increased by cholestyramine administration, which prevented the formation of cholesterol stones.
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TLDR
It is suggested that the pattern of the bile acids synthesized may roughly reflect the degree of hepatic cholesterogenesis in normolipidemic and hypertriglyceridemic subjects.
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TLDR
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TLDR
In human liver a parallel stimulation of cholesterol synthesis and LDL receptor expression occurs in response to stimulation of bile acid synthesis, suggesting a simultaneous stimulatory effect to compensate for the increased hepatic cholesterol catabolism due to bile acids depletion caused by cholestyramine.
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TLDR
The results support the proposal that steroid 12 alpha-hydroxylase is a major factor in determining the relative proportion of cholic acid and chenodeoxycholic acid synthesized in the liver and indicate that cholesterol feeding increased percentage of chenodesoxycholics acid by inhibiting the activity of steroid 12alpha-hydroxyylase.
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TLDR
P pigment gallstones were induced in less than 8 wk in hamsters fed estrogen-supplemented purified diets, apparently through its impact on large bowel metabolism and lactose feeding improved lipid metabolism and reduced gallstone formation.
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