Modeling panic disorder in rodents

  title={Modeling panic disorder in rodents},
  author={Fabr{\'i}cio A. Moreira and Pedro H Gobira and Th{\'e}rcia Guedes Viana and Maria Adrielle Vicente and H{\'e}lio Zangrossi and Frederico Guilherme Graeff},
  journal={Cell and Tissue Research},
Panic disorder (PD) is a subtype of anxiety disorder in which the core phenomenon is the spontaneous occurrence of panic attacks. Although studies with laboratory animals have been instrumental for the understanding of its neurobiology and treatment, few review articles have focused on the validity of the currently used animal models for studying this psychopathology. Therefore, the aim of the present paper is to discuss the strengths and limits of these models in terms of face, construct and… 
Animal models for panic disorder.
The present article reviews the main models used in the current literature of panic disorder and an alternative/complementary model is proposed that uses zebrafish alarm reaction to study this disorder.
Panic disorder: attack of fear or acute attack of solitude? Convergences between affective neuroscience and phenomenological-Gestalt perspective
An alternative hypothesis about PD etiology is proposed: PD is mainly connected to the Panic system, that is activated in situations of separation from affective support and overexposure to the environment, putting into question the link between PD and activation of the Fear brain network.
Acid–base dysregulation and chemosensory mechanisms in panic disorder: a translational update
Current update on clinical and preclinical studies supporting how acid–base imbalance and diverse chemosensory mechanisms may be associated with PD are provided and future implications of these findings are discussed.
Novel investigational therapeutics for panic disorder
Very preliminary findings suggest that the antagonists of CRF1 and A-II receptors may have anti-panic properties, and biomarker-based strategies, pharmacogenomics, ‘personalized psychiatry’ and the NIH's Research Domain Criteria approach could help to remove obstacles limiting drug development.
Reappraising Preclinical Models of Separation Anxiety Disorder, Panic Disorder, and CO2 Sensitivity: Implications for Methodology and Translation into New Treatments.
The identification and improved understanding of biomarkers that link these mental health conditions under the guise of preclinical research models in conjunction with human longitudinal cohort studies can help resolve these issues.
Intravenous doxapram administration as a potential model of panic attacks in rats.
It is suggested that the cardiorespiratory and behavioral effects of doxapram in rodents serve as an experimental model that can provide insights into the neurobiology of panic attacks.
Rodent models of psychiatric disorders—practical considerations
A collection of review articles on animal models of depression, anxiety and schizophrenia, which still represent the core disorders of general psychiatry, are edited for a special issue of Cell and Tissue Research.


Neurobiology of panic disorder: From animal models to brain neuroimaging
It is shown that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and that ORX antagonists constitute a potential new treatment strategy for panic disorder.
The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders.
The reviewed results suggest that chronic, but not acute, administration of antidepressants suppress panic attacks by increasing the release of 5-HT and enhancing the responsivity of post-synaptic 5- HT1A and5-HT2A receptors in the DPAG.
Experimental panic provocation in healthy man—a translational role in anti-panic drug development?
  • M. Kellner
  • Psychology, Medicine
    Dialogues in clinical neuroscience
  • 2011
While CCK-4 panic was blocked by alprazolam pretreatment, escitalopram showed negative results in healthy man, and preliminary findings on novel investigational drugs and a few problematic results will be reviewed.
Predator-elicited plight responses in Swiss-Webster Mice: An experimental model of panic attacks
Induction of panic attack by stimulation of the ventromedial hypothalamus.
Findings obtained in an awake patient undergoing bilateral implantation of deep brain stimulation electrodes into the hypothalamus that strongly implicates the VMH as being critically involved in the genesis of panic attacks are reported.
Animal defense strategies and anxiety disorders.
Among conspecific interactions lies a forth defense strategy, submission, that has been related to normal social anxiety (shyness) and to Social Anxiety Disorder, which seems to be directly related to innate defense reactions.
Neural Pathways Underlying Lactate-Induced Panic
Neural circuits underlying lactate-induced panic-like responses and the involvement of both sympathetic and parasympathetic systems are elucidated.