Modeling panic disorder in rodents

@article{Moreira2013ModelingPD,
  title={Modeling panic disorder in rodents},
  author={Fabr{\'i}cio A. Moreira and Pedro H Gobira and Th{\'e}rcia Guedes Viana and Maria Adrielle Vicente and H{\'e}lio Zangrossi and Frederico Guilherme Graeff},
  journal={Cell and Tissue Research},
  year={2013},
  volume={354},
  pages={119-125}
}
Panic disorder (PD) is a subtype of anxiety disorder in which the core phenomenon is the spontaneous occurrence of panic attacks. Although studies with laboratory animals have been instrumental for the understanding of its neurobiology and treatment, few review articles have focused on the validity of the currently used animal models for studying this psychopathology. Therefore, the aim of the present paper is to discuss the strengths and limits of these models in terms of face, construct and… 
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It is suggested that the cardiorespiratory and behavioral effects of doxapram in rodents serve as an experimental model that can provide insights into the neurobiology of panic attacks.
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