Modeling oncology gene pathways network with multiple genotypes and phenotypes via a copula method

@article{Bao2009ModelingOG,
  title={Modeling oncology gene pathways network with multiple genotypes and phenotypes via a copula method},
  author={Le Bao and Zhou Zhu and Jingjing Ye},
  journal={2009 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology},
  year={2009},
  pages={237-246}
}
  • Le Bao, Zhou Zhu, Jingjing Ye
  • Published 30 March 2009
  • Biology
  • 2009 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology
Identification of interactions between molecular features (e.g. mutation, gene expression change) and gross phenotypes in diseases and other biological processes is one of the important challenges in genomic research. Popular approaches such as GSEA are limited to hypothesis tests of bivariate association. However, a specific phenotype is often dependent upon multiple molecular features. It is thus worth considering all possible interactions jointly for a more precise and realistic… 
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