• DOI:10.1109/CIBCB.2009.4925734
Corpus ID: 16779505

Modeling oncology gene pathways network with multiple genotypes and phenotypes via a copula method

@article{Bao2009ModelingOG,
  title={Modeling oncology gene pathways network with multiple genotypes and phenotypes via a copula method},
  author={Le Bao and Zhou Zhu and Jingjing Ye},
  journal={2009 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology},
  year={2009},
  pages={237-246}
}

Le Bao, Zhou Zhu, Jingjing Ye

Published 2009

Computer Science

2009 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology

Identification of interactions between molecular features (e.g. mutation, gene expression change) and gross phenotypes in diseases and other biological processes is one of the important challenges in genomic research. Popular approaches such as GSEA are limited to hypothesis tests of bivariate association. However, a specific phenotype is often dependent upon multiple molecular features. It is thus worth considering all possible interactions jointly for a more precise and realistic… CONTINUE READING

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