Modeling of the Binding of Octopamine and Dopamine in Insect Monoamine Transporters Reveals Structural and Electrostatic Differences.

@article{Arancibia2019ModelingOT,
  title={Modeling of the Binding of Octopamine and Dopamine in Insect Monoamine Transporters Reveals Structural and Electrostatic Differences.},
  author={Sandra Cort{\'e}s Arancibia and Matias Marambio and Jorge M Campusano and Ang{\'e}lica Fierro},
  journal={ACS chemical neuroscience},
  year={2019},
  volume={10 5},
  pages={
          2310-2317
        }
}
Octopamine, a trace amine in mammals, is a major neurotransmitter linked to important biological processes in insects. Interestingly, one of the molecular entities responsible for octopamine availability, the octopamine transporter (OAT), has not been identified in certain insect species. For instance, no OAT has been reported in the fly Drosophila melanogaster (Dm), and the molecule involved in octopamine reuptake in Drosophila is not known. Here, we used molecular modeling methodologies to… CONTINUE READING
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