Modeling of single noninactivating Na+ channels: evidence for two open and several fast inactivated states.

Abstract

Voltage-gated Na(+) channels play a fundamental role in the excitability of nerve and muscle cells. Defects in fast Na(+) channel inactivation can cause hereditary muscle diseases with hyper- or hypoexcitability of the sarcolemma. To explore the kinetics and gating mechanisms of noninactivating muscle Na(+) channels on a molecular level, we analyzed single… (More)

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@article{The2006ModelingOS, title={Modeling of single noninactivating Na+ channels: evidence for two open and several fast inactivated states.}, author={Yu-Kai The and Jacqueline Fernandes and Mariana Oana Popa and Alexi K. Alekov and Jens Timmer and Holger Lerche}, journal={Biophysical journal}, year={2006}, volume={90 10}, pages={3511-22} }