Modeling of sertindole pharmacokinetic disposition in healthy volunteers in short term dose-escalation studies.

@article{Wong1998ModelingOS,
  title={Modeling of sertindole pharmacokinetic disposition in healthy volunteers in short term dose-escalation studies.},
  author={Shekman L. Wong and G. Richard Granneman},
  journal={Journal of pharmaceutical sciences},
  year={1998},
  volume={87 12},
  pages={1629-31}
}
The pharmacokinetics of sertindole were studied in young, healthy volunteers after single and multiple oral dose administered under an escalating manner. In a low-dose study (study 1), subjects received 4-8 mg with a maintenance dose period of 7 days. In a high-dose study (study 2), subjects received 4 mg daily for 2 days, and the dose was increased by 4 mg increments every third day until reaching 20 mg daily. The mean terminal t 1,2 was 73 h after the final 8 mg dose in study 1 and 60 h after… CONTINUE READING

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