Modeling of seizure transitions with ion concentration dynamics


Traditionally it is considered that neuronal synchronization in epilepsy is caused by a chain reaction of synaptic excitation. However, it has been shown that synaptic transmission is not necessary for epileptiform synchronization [1]. In order to investigate the respective roles of synaptic and non-synaptic neuronal coupling in seizure transitions, we… (More)
DOI: 10.1186/1471-2202-16-S1-P242


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