Modeling of receptor mimics that inhibit superantigen pathogenesis.

  title={Modeling of receptor mimics that inhibit superantigen pathogenesis.},
  author={Margit M{\"o}llhoff and Hannah B. Vander Zanden and Patrick R Shiflett and Goutam Gupta},
  journal={Journal of molecular recognition : JMR},
  volume={18 1},
Staphylococcal enterotoxins SEB and SEC3 and toxic shock syndrome toxin TSST-1 act as superantigens by overstimulating the human immune system and thereby compromise host defense. The mechanism of pathogenesis is explained on the basis of superantigen binding to the MHC class II receptor on the antigen presenting cell and to the T cell receptor (TcR) on the T cell. SEB, SEC3 and TSST-1 bind as intact proteins and make contacts with the alpha1 subdomain (DRalpha) of MHC class II and Vbeta… CONTINUE READING