Modeling of interstitial fluid pressure in solid tumor

@article{Pusenjak2000ModelingOI,
  title={Modeling of interstitial fluid pressure in solid tumor},
  author={Jani Pusenjak and Damijan Miklavcic},
  journal={Simul. Pr. Theory},
  year={2000},
  volume={8},
  pages={17-24}
}
Interstitial ̄uid pressure (IFP) is one of the main obstacles for macromolecular agents uptake and distribution in solid tumors. It has been demonstrated to reduce e€ectiveness of different macromolecular agents used in in vivo anti-tumor therapies, which on the other hand showed very good anti-tumor properties in in vitro conditions [L.T. Baxter, R.K. Jain, Microvascular Research 37 (1989) 77±104]. With an appropriate model we demonstrated the correlation between di€erent physiological… CONTINUE READING
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