Modeling of interstitial fluid pressure in solid tumor

  title={Modeling of interstitial fluid pressure in solid tumor},
  author={Jani Pusenjak and Damijan Miklavcic},
  journal={Simul. Pr. Theory},
Interstitial ̄uid pressure (IFP) is one of the main obstacles for macromolecular agents uptake and distribution in solid tumors. It has been demonstrated to reduce e€ectiveness of different macromolecular agents used in in vivo anti-tumor therapies, which on the other hand showed very good anti-tumor properties in in vitro conditions [L.T. Baxter, R.K. Jain, Microvascular Research 37 (1989) 77±104]. With an appropriate model we demonstrated the correlation between di€erent physiological… CONTINUE READING
9 Citations
17 References
Similar Papers


Publications citing this paper.
Showing 1-9 of 9 extracted citations


Publications referenced by this paper.
Showing 1-10 of 17 references

Textbook of Medical Physiology ± ninth edition

  • A. C. Guyton, J. E. Hall
  • Unit IV ± The Circulation & Unit V ± The Kidneys…
  • 1996
2 Excerpts

Pharmacologic modi®cation of tumor blood ̄ow and interstitial ̄uid pressure in a human tumor xenograft: Network analysis and mechanistic interpretation

  • R. A. Zlotecky
  • Microvascular Research
  • 1995
1 Excerpt

Similar Papers

Loading similar papers…