Modeling of glutamate-Induced Dynamical Patterns

  title={Modeling of glutamate-Induced Dynamical Patterns},
  author={N. C. K. Bentzen and Anatol M. Zhabotinsky and J. L. Laugesen},
  journal={International journal of neural systems},
  volume={19 6},
Based on established physiological mechanisms, the paper presents a detailed computer model, which supports the hypothesis that temporal lobe epilepsy may be caused by failure of glutamate reuptake from the extracellular space. The elevated glutamate concentration causes an increased activation of NMDA receptors in pyramidal neurons, which in turn leads to neuronal dynamics that is qualitatively identical to epileptiform activity. We identify by chaos analysis a surprising possibility that… CONTINUE READING


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