Modeling of enzyme–substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10

@article{Manzetti2003ModelingOE,
  title={Modeling of enzyme–substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10},
  author={Sergio Manzetti and Daniel R. McCulloch and Adrian C. Herington and David van der Spoel},
  journal={Journal of Computer-Aided Molecular Design},
  year={2003},
  volume={17},
  pages={551-565}
}
The matrix metalloproteases (MMPs) and the ADAMs (A Disintegrin And Metalloprotease domain) are proteolytic enzyme families containing a catalytic zinc ion, that are implicated in a variety of normal and pathological processes involving tissue remodeling and cancer. Synthetic MMP inhibitors have been designed for applications in pathological situations. However, a greater understanding of substrate binding and the catalytic mechanism is required so that more effective and selective inhibitors… Expand
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