Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).
@article{Siepmann2001ModelingOD,
title={Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).},
author={Juergen Siepmann and Nicholas A. Peppas},
journal={Advanced drug delivery reviews},
year={2001},
volume={48 2-3},
pages={
139-57
}
}
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A novel mathematical model for the water transport into and drug release from hydroxypropyl methylcellulose (HPMC) tablets is presented and it is shown that the diffusion coefficients strongly depend on the water concentration.
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The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
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