Modeling of dose-response-time data: four examples of estimating the turnover parameters and generating kinetic functions from response profiles.

@article{Gabrielsson2000ModelingOD,
  title={Modeling of dose-response-time data: four examples of estimating the turnover parameters and generating kinetic functions from response profiles.},
  author={Johan Gabrielsson and William J. Jusko and L Alari},
  journal={Biopharmaceutics & drug disposition},
  year={2000},
  volume={21 2},
  pages={41-52}
}
The most common approach to in vivo pharmacokinetic and pharmacodynamic modeling involves sequential analysis of the plasma concentration versus time and then response versus time data, such that the plasma kinetic model provides an independent function, driving the dynamics. However, response versus time data, even in the absence of measured drug concentrations, inherently contain useful information about the turnover characteristics of response (turnover rate, half-life of response), the drug… CONTINUE READING

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Dose-response-time modelling: Second-generation turnover model with integral feedback control.

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