Modeling of Menkes disease via human induced pluripotent stem cells.


Menkes disease (MD) is a copper-deficient neurodegenerative disorder that manifests severe neurologic symptoms such as seizures, lethargic states, and hypotonia. Menkes disease is due to a dysfunction of ATP7A, but the pathophysiology of neurologic manifestation is poorly understood during embryonic development. To understand the pathophysiology of… (More)
DOI: 10.1016/j.bbrc.2014.01.038

6 Figures and Tables


  • Presentations referencing similar topics