Modeling of Menkes disease via human induced pluripotent stem cells.

Abstract

Menkes disease (MD) is a copper-deficient neurodegenerative disorder that manifests severe neurologic symptoms such as seizures, lethargic states, and hypotonia. Menkes disease is due to a dysfunction of ATP7A, but the pathophysiology of neurologic manifestation is poorly understood during embryonic development. To understand the pathophysiology of… (More)
DOI: 10.1016/j.bbrc.2014.01.038

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