Modeling of Environmental Effects in Genome-Wide Association Studies Identifies SLC2A2 and HP as Novel Loci Influencing Serum Cholesterol Levels

@inproceedings{Igl2010ModelingOE,
  title={Modeling of Environmental Effects in Genome-Wide Association Studies Identifies SLC2A2 and HP as Novel Loci Influencing Serum Cholesterol Levels},
  author={Wilmar Igl and {\AA}sa Johansson and James F Wilson and Sarah H Wild and Ozren Pola{\vs}ek and Caroline Hayward and Veronique Vitart and Nicholas D Hastie and Pavao Rudan and Carsten Gnewuch and Gerd Schmitz and Thomas Meitinger and Peter P. Pramstaller and Andrew A Hicks and Ben A. Oostra and Cornelia M van Duijn and Igor Rudan and Alan F. Wright and Harry Campbell and Ulf Gyllensten},
  booktitle={PLoS genetics},
  year={2010}
}
Genome-wide association studies (GWAS) have identified 38 larger genetic regions affecting classical blood lipid levels without adjusting for important environmental influences. We modeled diet and physical activity in a GWAS in order to identify novel loci affecting total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels. The Swedish (SE) EUROSPAN cohort (N(SE) = 656) was screened for candidate genes and the non-Swedish (NS) EUROSPAN cohorts (N(NS) = 3,282) were used for… CONTINUE READING
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