Modeling of Brain D2 Receptor Occupancy‐Plasma Concentration Relationships with a Novel Antipsychotic, YKP1358, Using Serial PET Scans in Healthy Volunteers

@article{Lim2007ModelingOB,
  title={Modeling of Brain D2 Receptor Occupancy‐Plasma Concentration Relationships with a Novel Antipsychotic, YKP1358, Using Serial PET Scans in Healthy Volunteers},
  author={K. Lim and J. Kwon and I. Jang and J. Jeong and J. Lee and H. Kim and W. J. Kang and J. Kim and J. Cho and E. Kim and S. Yoo and S-G Shin and K-S Yu},
  journal={Clinical Pharmacology & Therapeutics},
  year={2007},
  volume={81}
}
YKP1358 is a novel serotonin (5‐HT2A) and dopamine (D2) antagonist that, in preclinical studies, fits the general profile of an atypical antipsychotic. We conducted a D2 receptor occupancy study with YKP1358 in healthy volunteers using positron emission tomography (PET) to measure the D2 receptor occupancy of YKP1358 and to characterize its relationship to plasma drug concentrations. A single oral dose, parallel group, dose‐escalation (100, 200, and 250 mg) study was performed in 10 healthy… Expand
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