Modeling neurodegenerative diseases in Caenorhabditis elegans.

  title={Modeling neurodegenerative diseases in Caenorhabditis elegans.},
  author={Jia Li and Weidong Le},
  journal={Experimental neurology},
Neurodegenerative diseases which include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington disease (HD), and others are becoming an increasing threat to human health worldwide. The degeneration and death of certain specific groups of neurons are the hallmarks of these diseases. Despite the research progress in identification of several disease-related genes, the mechanisms underlying the neurodegeneration in these diseases remain unclear. Given… CONTINUE READING