Modeling motor neuron disease: the matter of time.

  title={Modeling motor neuron disease: the matter of time.},
  author={Mandana Arbab and Susanne E Baars and Niels Geijsen},
  journal={Trends in neurosciences},
  volume={37 11},
Stem cell technologies have created new opportunities to generate unlimited numbers of human neurons in the lab and study neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Although some disease hallmarks have been reported in patient-derived stem cell models, it is proving more difficult to recapitulate the full phenotypic extent of these disorders. The problem with these stem cell models lies in the disparity between the advanced age of… CONTINUE READING