Modeling micropatterned antigen-antibody binding kinetics in a microfluidic chip.

@article{Hu2007ModelingMA,
  title={Modeling micropatterned antigen-antibody binding kinetics in a microfluidic chip.},
  author={Guoqing Hu and Yali Gao and Dongqing Li},
  journal={Biosensors & bioelectronics},
  year={2007},
  volume={22 7},
  pages={1403-9}
}
The reaction kinetics of antigen-antibody binding in the electrokinetically controlled microfluidic heterogeneous immunoassays has been investigated by numerical simulations. A two-dimensional computational model was employed to include the mass transport (convection and diffusion) and binding reaction between the antigen in the bulk flow and the immobilized antibody at the channel surface. The influence of the bulk velocity, the concentrations of the antibody and antigen, and the geometry of… CONTINUE READING
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