Modeling microarray data using a threshold mixture model.

@article{Kauermann2004ModelingMD,
  title={Modeling microarray data using a threshold mixture model.},
  author={G{\"o}ran Kauermann and Paul Eilers},
  journal={Biometrics},
  year={2004},
  volume={60 2},
  pages={
          376-87
        }
}
An important goal of microarray studies is the detection of genes that show significant changes in expression when two classes of biological samples are being compared. We present an ANOVA-style mixed model with parameters for array normalization, overall level of gene expression, and change of expression between the classes. For the latter we assume a mixing distribution with a probability mass concentrated at zero, representing genes with no changes, and a normal distribution representing the… CONTINUE READING

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