Modeling membrane proteins based on low-resolution electron microscopy maps: a template for the TM domains of the oxalate transporter OxlT.

@article{Beuming2005ModelingMP,
  title={Modeling membrane proteins based on low-resolution electron microscopy maps: a template for the TM domains of the oxalate transporter OxlT.},
  author={Thijs Beuming and Harel Weinstein},
  journal={Protein engineering, design & selection : PEDS},
  year={2005},
  volume={18 3},
  pages={
          119-25
        }
}
  • Thijs Beuming, Harel Weinstein
  • Published in
    Protein engineering, design…
    2005
  • Medicine, Chemistry
  • The availability of both EM and high-resolution crystallographic data for several membrane proteins (MPs) permits a detailed evaluation of the ability of molecular modeling techniques to complement EM data in the development of models of MPs. A protocol for this purpose is presented, consisting of (1) identifying transmembrane (TM) domains from sequence; (2) assigning buried and lipid-exposed faces of the TM domains; and (3) assembling the TM domains into a bundle, based on geometric restraints… CONTINUE READING

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