Modeling insulin action for development of a closed-loop artificial pancreas.

@article{Steil2005ModelingIA,
  title={Modeling insulin action for development of a closed-loop artificial pancreas.},
  author={Garry M. Steil and Bud Clark and Sami Kanderian and Kerstin Rebrin},
  journal={Diabetes technology & therapeutics},
  year={2005},
  volume={7 1},
  pages={94-108}
}
Three models of glucose homeostasis are compared in terms of their steady-state dose-response characteristics, how they characterize glucose distribution kinetics, and how they characterize the dynamics of insulin action. The three models [minimal model, AIDA (Automated Insulin Dosage Advisor), and a model by Sorensen] are used to discuss a wider variety of questions related to metabolic modeling. Simulations are performed comparing each model's response to an intravenous glucose tolerance test… CONTINUE READING