Modeling industrial centrifugation of mammalian cell culture using a capillary based scale-down system.

Abstract

Continuous-flow centrifugation is widely utilized as the primary clarification step in the recovery of biopharmaceuticals from cell culture. However, it is a challenging operation to develop and characterize due to the lack of easy to use, small-scale, systems that can be used to model industrial processes. As a result, pilot-scale continuous centrifugation… (More)
DOI: 10.1002/bit.23051

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