Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression.

@article{Reuter2009ModelingIH,
  title={Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression.},
  author={Jason A. Reuter and Susana M. Ortiz-Urda and Markus Kretz and John J. Garcia and Florence A. Scholl and Anna M. G. Pasmooij and David Cassarino Cassarino and Howard Y Chang and Paul A. Khavari},
  journal={Cancer cell},
  year={2009},
  volume={15 6},
  pages={477-88}
}
To elucidate mechanisms of cancer progression, we generated inducible human neoplasia in three-dimensionally intact epithelial tissue. Gene expression profiling of both epithelia and stroma at specific time points during tumor progression revealed sequential enrichment of genes mediating discrete biologic functions in each tissue compartment. A core cancer progression signature was distilled using the increased signaling specificity of downstream oncogene effectors and subjected to network… CONTINUE READING

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