Modeling hyperosmotic blood–brain barrier opening within human tissue-engineered in vitro brain microvessels

@article{Linville2019ModelingHB,
  title={Modeling hyperosmotic blood–brain barrier opening within human tissue-engineered in vitro brain microvessels},
  author={Raleigh M. Linville and Jackson G. DeStefano and Matt B Sklar and Chengyan Chu and Piotr Walczak and Peter C. Searson},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={2019},
  volume={40},
  pages={1517 - 1532}
}
As the majority of therapeutic agents do not cross the blood–brain barrier (BBB), transient BBB opening (BBBO) is one strategy to enable delivery into the brain for effective treatment of CNS disease. Intra-arterial infusion of the hyperosmotic agent mannitol reversibly opens the BBB; however, widespread clinical use has been limited due to the variability in outcomes. The current model for mannitol-induced BBBO assumes a transient but homogeneous increase in permeability; however, the details… Expand
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