Modeling human interindividual variability in metabolism and risk: the example of 4-aminobiphenyl.

@article{Bois1995ModelingHI,
  title={Modeling human interindividual variability in metabolism and risk: the example of 4-aminobiphenyl.},
  author={Fr{\'e}d{\'e}ric Y. Bois and G Krowech and Lauren Zeise},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={1995},
  volume={15 2},
  pages={205-13}
}
We investigate, through modeling, the impact of interindividual heterogeneity in the metabolism of 4-aminobiphenyl (ABP) and in physiological factors on human cancer risk: A physiological pharmacokinetic model was used to quantify the time course of the formation of the proximate carcinogen, N-hydroxy-4-ABP and the DNA-binding of the active species in the bladder. The metabolic and physiologic model parameters were randomly varied, via Monte Carlo simulations, to reproduce interindividual… CONTINUE READING

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