Modeling high-grade serous ovarian carcinogenesis from the fallopian tube.

@article{Karst2011ModelingHS,
  title={Modeling high-grade serous ovarian carcinogenesis from the fallopian tube.},
  author={Alison M. Karst and Keren Levanon and Ronny Drapkin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 18},
  pages={
          7547-52
        }
}
High-grade serous ovarian carcinoma (HGSOC) is a lethal disease for which improved screening and treatment strategies are urgently needed. Progress in these areas is impeded by our poor understanding of HGSOC pathogenesis. Most ovarian cancer research is based on the hypothesis that HGSOC arises from ovarian surface epithelial cells. However, recent studies suggest that >50% of high-grade serous carcinomas involving the ovary likely arise from fallopian tube epithelium. Therefore, limiting… CONTINUE READING

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