Modeling fragile X syndrome in the Fmr1 knockout mouse.

  title={Modeling fragile X syndrome in the Fmr1 knockout mouse.},
  author={Tatiana M Kazdoba and Prescott T. Leach and Jill L Silverman and Jacqueline N. Crawley},
  journal={Intractable & rare diseases research},
  volume={3 4},
Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of FXS can include impaired cognition, anxiety, hyperactivity, social phobia, and repetitive behaviors. FXS is caused by a CGG repeat mutation which expands a region on the X chromosome containing the FMR1 gene. In FXS, a full mutation (> 200 repeats) leads to hypermethylation of FMR1, an epigenetic mechanism that effectively… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 40 extracted citations


Publications referenced by this paper.
Showing 1-10 of 212 references

Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome.

The international journal of neuropsychopharmacology • 2011
View 4 Excerpts
Highly Influenced

Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses.

Autism research : official journal of the International Society for Autism Research • 2011
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…