Modeling fibril fragmentation in real-time.

  title={Modeling fibril fragmentation in real-time.},
  author={Pengzhen Tan and Liu Hong},
  journal={The Journal of chemical physics},
  volume={139 8},
During the application of the mass-action-equation models to the study of amyloid fiber formation, time-consuming numerical calculations constitute a major bottleneck. To conquer this difficulty, here an alternative efficient method is introduced for the fragmentation-only model. It includes two basic steps: (1) simulate close-formed time-evolutionary equations for the number concentration P(t) derived from the moment-closure method; (2) reconstruct the detailed fiber length distribution based… CONTINUE READING