Modeling feedback loops of the Mammalian circadian oscillator.

  title={Modeling feedback loops of the Mammalian circadian oscillator.},
  author={Sabine Becker-Weimann and Jana Wolf and Hanspeter Herzel and Achim Kramer},
  journal={Biophysical journal},
  volume={87 5},
The suprachiasmatic nucleus governs daily variations of physiology and behavior in mammals. Within single neurons, interlocked transcriptional/translational feedback loops generate circadian rhythms on the molecular level. We present a mathematical model that reflects the essential features of the mammalian circadian oscillator to characterize the differential roles of negative and positive feedback loops. The oscillations that are obtained have a 24-h period and are robust toward parameter… CONTINUE READING
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