Modeling fatigue over sleep deprivation, circadian rhythm, and caffeine with a minimal performance inhibitor model.

@article{Benitez2009ModelingFO,
  title={Modeling fatigue over sleep deprivation, circadian rhythm, and caffeine with a minimal performance inhibitor model.},
  author={Patrick L Benitez and Gary H. Kamimori and Thomas J. Balkin and Alexander Greene and Michael D. Johnson},
  journal={Methods in enzymology},
  year={2009},
  volume={454},
  pages={405-21}
}
Sleep loss, as well as concomitant fatigue and risk, is ubiquitous in today's fast-paced society. A biomathematical model that succeeds in describing performance during extended wakefulness would have practical utility in operational environments and could help elucidate the physiological basis of sleep loss effects. Eighteen subjects (14 males, 4 females; age 25.8 +/- 4.3 years) with low levels of habitual caffeine consumption (<300 mg/day) participated. On night 1, subjects slept for 8 h… CONTINUE READING

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