Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.

Abstract

Familial Danish dementia (FDD) is a progressive neurodegenerative disease with cerebral deposition of Dan-amyloid (ADan), neuroinflammation, and neurofibrillary tangles, hallmark characteristics remarkably similar to those in Alzheimer's disease (AD). We have generated transgenic (tg) mouse models of familial Danish dementia that exhibit the age-dependent… (More)
DOI: 10.1073/pnas.1001056107

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@article{Coomaraswamy2010ModelingFD, title={Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.}, author={Janaky Coomaraswamy and Ellen Kilger and Heidrun Woelfing and Claudia Schaefer and Stephan A. Kaeser and Bettina M. Wegenast-Braun and Jasmin K. Hefendehl and Hartwig Wolburg and Matthew J. Mazzella and Jorge A. Ghiso and Michel Goedert and Haruhiko Akiyama and Francisco Garc{\'i}a-Sierra and David P Wolfer and Paul Mathews and Mathias Jucker}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2010}, volume={107 17}, pages={7969-74} }