Modeling extended twin family data I: description of the Cascade model.

  title={Modeling extended twin family data I: description of the Cascade model.},
  author={Matthew C. Keller and Sarah E. Medland and Laramie Duncan and Peter K Hatemi and Michael C. Neale and Hermine H Maes and Lindon J. Eaves},
  journal={Twin research and human genetics : the official journal of the International Society for Twin Studies},
  volume={12 1},
The classical twin design uses data on the variation of and covariation between monozygotic and dizygotic twins to infer underlying genetic and environmental causes of phenotypic variation in the population. By using data from additional relative classes, such as parents, extended twin family designs more comprehensively describe the causes of phenotypic variation. This article introduces an extension of previous extended twin family models, the Cascade model, which uses information on twins as… CONTINUE READING

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