Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps.

@article{Finegood1988ModelingEA,
  title={Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps.},
  author={Diane T. Finegood and Richard N Bergman and Mladen Vranic},
  journal={Diabetes},
  year={1988},
  volume={37 8},
  pages={1025-34}
}
We previously demonstrated that conventional tracer methods applied to euglycemic-hyperinsulinemic glucose clamps result in substantially negative estimates for the rate of endogenous glucose production, particularly during the first half of 180-min clamps. We also showed that addition of tracer to the exogenous glucose infusate resulted in nonnegative endogenous glucose production (Ra) estimates. In this study, we investigated the underlying cause of negative estimates of Ra from conventional… CONTINUE READING

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