Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes.

@article{Dziuba2014ModelingEO,
  title={Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes.},
  author={John Dziuba and Peter E. Alperin and Jill Racketa and Uchenna H. Iloeje and Debabrata Goswami and Elise Hardy and Itay Perlstein and Helene L. Grossman and Mickael Cohen},
  journal={Diabetes, obesity & metabolism},
  year={2014},
  volume={16 7},
  pages={628-35}
}
AIMS Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor, has been shown to lower glycated hemoglobin (HbA1c), weight, blood pressure and serum uric acid in clinical trials. Plasma lipids were also evaluated as exploratory variables. The goal of this study was to estimate the long-term cardiovascular (CV) and microvascular outcomes of dapagliflozin added to the standard of care (SOC) versus SOC using simulation methodology. METHODS The Archimedes Model, a validated model of… CONTINUE READING
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