Modeling early retinal development with human embryonic and induced pluripotent stem cells.

  title={Modeling early retinal development with human embryonic and induced pluripotent stem cells.},
  author={Jason S. Meyer and Rebecca L. Shearer and Elizabeth E. Capowski and Lynda S. Wright and Kyle Wallace and Erin L. McMillan and Su-chun Zhang and David M Gamm},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 39},
Human pluripotent stem cells have the potential to provide comprehensive model systems for the earliest stages of human ontogenesis. To serve in this capacity, these cells must undergo a targeted, stepwise differentiation process that follows a normal developmental timeline. Here we demonstrate the ability of both human embryonic stem cells (hESCs) and induced pluripotent stem (iPS) cells to meet these requirements for human retinogenesis. Upon differentiation, hESCs initially yielded a highly… CONTINUE READING
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