Modeling diseases in multiple mouse strains for precision medicine studies.


The genetic basis of the phenotypic variability observed in patients can be studied in mice by generating disease models through genetic or chemical interventions in many genetic backgrounds where the clinical phenotypes can be assessed and used for genome-wide association studies (GWAS). This is particularly relevant for rare disorders, where patients… (More)
DOI: 10.1152/physiolgenomics.00123.2016


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