Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies.

@article{Haarer2007ModelingCG,
  title={Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies.},
  author={Brian K Haarer and Susan C Viggiano and Mathew A Hibbs and Olga G. Troyanskaya and David C. Amberg},
  journal={Genes & development},
  year={2007},
  volume={21 2},
  pages={148-59}
}
Multigenic influences are major contributors to human genetic disorders. Since humans are highly polymorphic, there are a high number of possible detrimental, multiallelic gene pairs. The actin cytoskeleton of yeast was used to determine the potential for deleterious bigenic interactions; approximately 4800 complex hemizygote strains were constructed between an actin-null allele and the nonessential gene deletion collection. We found 208 genes that have deleterious complex haploinsufficient… CONTINUE READING