Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies.

@article{Haarer2007ModelingCG,
  title={Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies.},
  author={B. Haarer and S. Viggiano and Mathew A Hibbs and O. Troyanskaya and D. Amberg},
  journal={Genes & development},
  year={2007},
  volume={21 2},
  pages={
          148-59
        }
}
  • B. Haarer, S. Viggiano, +2 authors D. Amberg
  • Published 2007
  • Medicine, Biology
  • Genes & development
  • Multigenic influences are major contributors to human genetic disorders. Since humans are highly polymorphic, there are a high number of possible detrimental, multiallelic gene pairs. The actin cytoskeleton of yeast was used to determine the potential for deleterious bigenic interactions; approximately 4800 complex hemizygote strains were constructed between an actin-null allele and the nonessential gene deletion collection. We found 208 genes that have deleterious complex haploinsufficient… CONTINUE READING

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