Modeling coding-sequence evolution within the context of residue solvent accessibility

@inproceedings{Scherrer2012ModelingCE,
  title={Modeling coding-sequence evolution within the context of residue solvent accessibility},
  author={Michael Paul Scherrer and Austin G. Meyer and Claus O. Wilke},
  booktitle={BMC Evolutionary Biology},
  year={2012}
}
BackgroundProtein structure mediates site-specific patterns of sequence divergence. In particular, residues in the core of a protein (solvent-inaccessible residues) tend to be more evolutionarily conserved than residues on the surface (solvent-accessible residues).ResultsHere, we present a model of sequence evolution that explicitly accounts for the relative solvent accessibility of each residue in a protein. Our model is a variant of the Goldman-Yang 1994 (GY94) model in which all model… CONTINUE READING
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