Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms

@article{Farrell2018ModelingCR,
  title={Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms},
  author={Mitchell R. Farrell and Hannah Schoch and Stephen V Mahler},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2018},
  volume={87},
  pages={33-47}
}
Addiction is a chronic relapsing disorder, in that most addicted individuals who choose to quit taking drugs fail to maintain abstinence in the long-term. Relapse is especially likely when recovering addicts encounter risk factors like small "priming" doses of drug, stress, or drug-associated cues and locations. In rodents, these same factors reinstate cocaine seeking after a period of abstinence, and extensive preclinical work has used priming, stress, or cue reinstatement models to uncover… CONTINUE READING
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The reinstatement model

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