Modeling coating flow and surfactant dynamics inside the alveolar compartment

@article{Kang2018ModelingCF,
  title={Modeling coating flow and surfactant dynamics inside the alveolar compartment},
  author={Di Kang and Marina Chugunova and Ali Nadim and Alan J. Waring and Frans J. Walther},
  journal={Journal of Engineering Mathematics},
  year={2018},
  volume={113},
  pages={23-43}
}
We derive a new model for the coating flow inside the alveolar compartment, taking into account pulmonary surfactant production and recycling by Type 2 cells as well as its degradation. As the thickness of alveolar coating is much smaller than the average radius of the alveoli, we employ the classical lubrication approximation to describe the thin liquid film dynamics in the presence of pulmonary surfactant, which is a surface tension-reducing agent and thus prevents the lungs from collapse. In… 
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References

SHOWING 1-10 OF 49 REFERENCES
The dynamics of a localized surfactant on a thin film
We investigate the flow induced by a localized insoluble surfactant on a thin film. This problem is intended to model the behaviour of the lung's thin-film lining after an aerosol droplet lands on
A theoretical study of surfactant and liquid delivery into the lung.
TLDR
Numerical solutions show that both transit and delivery times are strongly influenced by the strength of the preexisting surfactant and the geometric properties of the airway network.
A model of flow and surfactant transport in an oscillatory alveolus partially filled with liquid
The flow and transport in an alveolus are of fundamental importance to partial liquid ventilation, surfactant transport, pulmonary drug administration, cell-cell signaling pathways, and gene therapy.
Insoluble surfactant spreading on a thin viscous film: shock evolution and film rupture
Lubrication theory and similarity methods are used to determine the spreading rate of a localized monolayer of insoluble surfactant on the surface of a thin viscous film, in the limit of weak
Flow of surfactant-laden thin films down an inclined plane
Abstract.A theory is formulated to describe the dynamics of a thin film flowing down an inclined plane laden with insoluble surfactant, present in dilute concentrations. Use of lubrication theory
Marangoni effects on a thin liquid film coating a sphere with axial or radial thermal gradients
We study the time evolution of a thin liquid film coating the outer surface of a sphere in the presence of gravity, surface tension, and thermal gradients. We derive the fourth-order nonlinear
A CONCISE INTRODUCTION TO SURFACE RHEOLOGY WITH APPLICATION TO DILUTE EMULSIONS OF VISCOUS DROPS
A concise review is provided of fundamentals of interfacial transport and rheology, which includes simple proofs of the surface divergence theorem and the surface Reynolds transport theorem, needed
The interface dynamics of a surfactant drop on a thin viscous film†
We study a system of two coupled parabolic equations that models the spreading of a drop of an insoluble surfactant on a thin liquid film. Unlike the previously known results, the surface diffusion
Thin film equations with soluble surfactant and gravity: Modeling and stability of steady states
A thin film on a horizontal solid substrate and coated with a soluble surfactant is considered. The governing degenerate parabolic equations for the film height and the surfactant concentrations on
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