Modeling cancer processes with CRISPR-Cas9.

Abstract

CRISPR-Cas9 is an RNA-guided site-specific DNA editing tool which, together with its reprogrammed versions such as nickase Cas9 and dead Cas9, enables quick modeling of desired combinations of cancer-associated genomic and/or epigenetic aberrations simultaneously or sequentially, thus facilitating massive functional interrogations and therapy testing. 
DOI: 10.1016/j.tibtech.2015.03.007

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