Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.

@article{Wulf2004ModelingBC,
  title={Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.},
  author={Gerburg M Wulf and Priti Garg and Yih-Cherng Liou and Dirk J Iglehart and Kun Lu},
  journal={The EMBO journal},
  year={2004},
  volume={23 16},
  pages={3397-407}
}
Phosphorylation on certain Ser/Thr-Pro motifs is a major oncogenic mechanism. The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1. Pin1 is prevalently overexpressed in human cancers and implicated in oncogenesis. However, the role of Pin1 in oncogenesis in vivo is not known. We have shown that Pin1 ablation is highly effective in preventing oncogenic Neu or Ras from inducing cyclin D1 and breast cancer in mice, although it… CONTINUE READING

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Pin1 is overexpressed in breast cancer and potentiates the transcriptional activity of phosphorylated c-Jun towards the cyclin D1 gene

  • GM Wulf, A Ryo, GG Wulf, SW Lee, T Niu, KP Lu
  • EMBO J
  • 2001
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