Modeling bacterial immune systems: Strategies for expression of toxic - but useful - molecules

Abstract

Protection of bacterial cells against virus infection requires expression of molecules that are able to destroy the incoming foreign DNA. However, these molecules can also be toxic for the host cell. In both restriction-modification (R-M), and the recently discovered CRISPR/Cas systems, the toxicity is (in part) avoided through rapid transition of the… (More)
DOI: 10.1016/j.biosystems.2013.03.004

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