Modeling asthma in mice: what have we learned about the airway epithelium?

  title={Modeling asthma in mice: what have we learned about the airway epithelium?},
  author={Jeremy A Hirota and Tillie L. Hackett and Mark D. Inman and Darryl A Knight},
  journal={American journal of respiratory cell and molecular biology},
  volume={44 4},
Clinical reports of areas of damaged airway epithelium associated with shed epithelial cells in bronchoalveolar lavage fluid, aberrant epithelial repair processes, and altered cytokine and growth factor release have highlighted some fundamental differences between the airway epithelium in individuals with and without asthma. However, the consequences of these epithelial changes are not clearly defined, and may be difficult to assess in the clinic. In this Review, we answer the two questions. (1… CONTINUE READING

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Effects of inhaled allergen on epithelial permeability and hypersensitivity

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